Solid dispersion of meloxicam: Factorially designed dosage form for geriatric population
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چکیده
منابع مشابه
Solid dispersion of meloxicam: factorially designed dosage form for geriatric population.
The objective of the present work was to improve the dissolution properties of the poorly water-soluble drug meloxicam by preparing solid dispersions with hydroxyethyl cellulose (HEC), mannitol and polyethylene glycol (PEG) 4000 and to develop a dosage form for geriatric population. Differential scanning calorimetry, X-ray diffractometry, Fourier transform infrared spectroscopy and scanning ele...
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The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...
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Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet. Methods: Crospovidone (CPV), a hydrophilic carrier was selected for SSD preparation on the basis of 89% in- vitro MLX adsorption, 19% hydrat...
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Solid dispersion complexes of meloxicam were prepared by using cyclodextrins (BCD, HPBCD), PVP and urea by kneading method in different molar and weight ratios. The complexes were characterized by DSC and IR, suggested that no chemical interaction between drug and carrier. The solubility, dissolution and permeability was studied for prepared complexes. The solubility, dissolution and permeabili...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2008
ISSN: 1846-9558,1330-0075
DOI: 10.2478/v10007-007-0048-y